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What The IDSA Knew In 1989

Based on their own publication.

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Supplement

Introduction

From the IDSA's Journal, Reviews of Infectious Diseases • Vol. 11, Supplement 6 • September-October 1989, Lyme Disease and Other Spirochetal Diseases. The publication describes Lyme disease as a very serious disabling infectious disease.

The description is very different from what they present today. The change occurred around the time of The Dearborn conference in 1994. The disease was redefined then as merely an arthritis of the knee with minor neurological symptoms. The change was done to make it look like a useless vaccine worked when it didn't work at all. The severe neurological symptoms were eliminated from the definition of Lyme disease because their inclusion would reveal the failure of the Lyme vaccine. The mild nourological complaints could be explained away since many things could cause them. The arthritis could be explained away as an autoimmune disease unrelated to Lyme. The severe neurological symptoms cannot be easily dismissed.

They designed the test so those with the more severe neurological issues would test negative. The severe neuro patients produce fewer antibodies than those with Lyme arthritis so deliberately raising the cutoff value led to most patients testing negative especially the worst neuro-patients.

These studies combined show that Lyme disease can be confused with multiple sclerosis, brain tumors, and dementia and can cause heart failure. Lyme can pass from the placenta to an unborn childs organs. Lyme disease is associated with birth defects, and fetal and infant deaths. Infants can be and have been born with Lyme disease. That hardly sounds like the Lyme disease the IDSA describes now.

The 1989 IDSA Journal,
Reviews of Infectious Diseases

Reviews of infectious diseases cover image.
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PMID: 2682960

Neurologic manifestations of Lyme disease, the new "great imitator".

They recognized the many similarities between the Syphilis spirochete and the Lyme spirochete. Lyme disease can be confused with multiple sclerosis, brain tumor, dementia, encephalitis, and psychiatric illness.
 
They knew then and they still know Lyme disease;

  • Can be confused with multiple sclerosis, brain tumors, dementia, and psychiatric illness. Symptoms like major paralysis, seizures, dementia, manic depression and more can all be caused by Lyme disease.
  • Invades the brain.
  • Can exist dormant in the central nervous system.

For thirty years now patients who have undiagnosed Lyme disease have been told these severe symptoms are not even real and they are sent off to a psychiatrist. The psychiatrist will tell them that they are imagining their illness and pump them full of psychiatric drugs. Power rules medicine, not science.

The causative agent of Lyme disease, Borrelia burgdorferi, is a highly neurotropic organism that not only can produce symptomatic neurologic disease but also can exist dormant within the central nervous system (CNS) for long periods.
It is not known how often the organism actually invades brain tissue as compared with the CSF or the leptomeninges, but it has been established that it does so.
I have seen patients whose conditions were confused with multiple sclerosis, brain tumor, dementia, encephalitis, and psychiatric illness before Lyme disease was finally diagnosed.
Lyme Disease Dementia MS
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PMID: 2682961

Immunologic aspects of Lyme borreliosis.

Neonatal Lyme Disease

In humans, B. burgdorferi is capable of infecting the fetus [35]. sequelae (including abortion and fetal abnormalities) have been associated with infection [36, 37]. The time, incidence, and morbidity of in utero infection are not known. However, both humoral and cellular B. burgdorferi-specific responses can be detected in cord blood of previously infected neonates (authors' unpublished observations). In addition, Borrelia-specific antibodies have been found in the CSF of an infant with evidence of neonatal neurologic dysfunction whose mother had been infected in the second trimester. The mother, who was asymptomatic, had been treated with oral antibiotics and did not have diagnostic levels of antibodies to B. burgdorferi at the time of parturition (authors' unpublished observations). Effective therapy to eradicate borreliae on both the maternal and the fetal side of the placenta is essential, as persistent infection may be difficult to diagnose after the initial course of antibiotics.
Congenital Lyme Disease
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PMID: 2814170

Clinical Pathologic Correlations of Lyme Disease.

Stage III involvement of cerebral parenchyma may manifest itself as dementia or other forms of psychiatric illness
Immature B cells can also be seen in the spinal fluid. These cells can appear quite atypical- not unlike those of transformed or neoplastic lymphocytes. Although it is known that spirochetes can be isolated from the spinal fluid, they are not recovered in all cases.
Biopsy of the sural nerve in patients with peripheral neuropathy associated with chronic Lyme disease has demonstrated the presence of lymphocytes and plasma cells in the nerve itself as well as in the perineural region (figure 10). This is not dissimilar to the pattern of infiltrates seen in stage II. What differentiates this complication from stage II involvement, however, is its apparent permanence. It can persist for years. With time, the vessels outside the nerve sheath become thickened and obliterated as do synovial vessels, a situation that suggests a component of ischemic damage may contribute to the neuropathy of chronic disease. Fibers within the nerve eventually lose myelin, a finding that has been demonstrated in both human patients and experimental animals. There is also evidence that a transverse myelitis of the spinal cord, suggestive of the Guillain-Barre syndrome, may be involved in some chronic infections.
Lyme Disease Dementia
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PMID: 2682963

Isolation Techniques for Spirochetes and Their Sensitivity to Antibiotics in Vitro and in Vivo.

Although spirochetes can often be detected in culture media after 3 weeks of culture, some isolates may not be visible for several months.
Lyme Disease
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PMID: 2682965

A Perspective on the Treatment of Lyme Borreliosis.

The aim of treatment of early Lyme disease during pregnancy is not only to treat the infection and prevent long-term sequelae but to eliminate the infection as quickly as possible so as to prevent congenital transmission to the fetus [53-55]. Recently, Weber et al. [56] reported the congenital transmission of B. burgdorferi to an infant whose mother had been treated with 1 million units of oral penicillin for 7 days.
 
Four referenced studies which show congenital transmission of Lyme disease to the fetus;
  1. Schlesinger PA, Duray PH, Burke BA, Steere AC, Stillman MT. Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med 1985;103:67-8
  2. MacDonald AB. Human fetal borreliosis, toxemia of pregnancy, and fetal death. Zentralbl Bakteriol Mikrobiol Hyg [A] 1986;263:189-200
  3. Markowitz LE, Steere AC, Benach JL, Slade JD, Broome CV. Lyme disease during pregnancy. JAMA 1986;255:3394-6
  4. Weber K, Bratzke H-J, Neubert U, Wilske B,Duray PH. Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis J 1988;7:286-9
Congenital Lyme Disease
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PMID: 2682962

Abnormalities of the Nervous System in Lyme Disease: Response to Antimicrobial Therapy.

Lyme disease can lead to severe pain and brain lesions.

Many patients with Lyme neuroborreliosis describe sensory symptoms. At one extreme, they may suffer severe radicular-type pain [1, 2].
Scan of brain lesion

Seven of the 16 patients with cognitive difficulties had focal white-matter abnormalities ... [figure 1]). None of the seven without encephalopathy had such lesions

Lyme Disease
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PMID: 2682958

Epidemiology and clinical similarities of human spirochetal diseases

Heart failure due to Lyme disease.

While the skin lesion is present (or shortly thereafter), the second stage of disease, characterized by cardiac or neurologic manifestations, begins. About 8% of patients develop various degrees of heart blockage, enlargement, or failure.
Lyme Disease
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Summary

Lyme disease can be confused with multiple sclerosis, brain tumors, and dementia and can cause heart failure. Lyme can pass from the placenta to an unborn childs organs. Lyme disease is associated with birth defects, and fetal and infant deaths. Infants can be and have been born with Lyme disease. The IDSA knows how severe Lyme disease really is.

Definitions

WORDS AND DEFINITIONS
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References

  1. Pachner AR. Neurologic manifestations of Lyme disease, the new "great imitator". Rev Infect Dis. 1989;11 Suppl 6:S1482-6.
  2. Dattwyler RJ, Volkman DJ, Luft BJ. Immunologic aspects of Lyme borreliosis. Rev Infect Dis. 1989;11 Suppl 6:S1494-8.
  3. Duray PH. Clinical pathologic correlations of Lyme disease. Rev Infect Dis. 1989;11 Suppl 6:S1487-93.
  4. Johnson RC. Isolation techniques for spirochetes and their sensitivity to antibiotics in vitro and in vivo. Rev Infect Dis. 1989;11 Suppl 6:S1505-10.
  5. Luft BJ, Gorevic PD, Halperin JJ, Volkman DJ, Dattwyler RJ. A perspective on the treatment of Lyme borreliosis. Rev Infect Dis. 1989;11 Suppl 6:S1518-25.
  6. Halperin JJ. Abnormalities of the nervous system in Lyme disease: response to antimicrobial therapy. Rev Infect Dis. 1989;11 Suppl 6:S1499-504.
  7. Schmid GP. Epidemiology and clinical similarities of human spirochetal diseases. Rev Infect Dis. 1989;11 Suppl 6:S1460-9.
ALL STUDIES ARE GOOD AND PRESUMED GOOD UNLESS CLEARLY STATED OTHERWISE.
Most of the studies presented are good studies. They are presented to shed light on the weak or fraudulent ones.